Executive Summary
- VDR gene variants are potentially associated with hypertensive disorders of pregnancy (HDP), but the association varies across different populations.
- PCR-RFLP is the most frequently used laboratory protocol for VDR variant detection; associations with FokI variant were found in Asian populations.
- Future research should focus on utilizing reliable detection methods and quality control measures to identify population-specific biomarkers and improve personalized management strategies for HDP.
Event Overview
A systematic review analyzed nine studies to investigate the laboratory detection protocols of vitamin D receptor (VDR) gene variants and their association with hypertensive disorders of pregnancy (HDP). The review found that genetic variations in the VDR gene have been inconsistently linked to HDP across different populations. The review aimed to evaluate the different VDR detection protocols and their association with HDP to enhance consistency in future research.
Media Coverage Comparison
| Source | Key Angle / Focus | Unique Details Mentioned | Tone |
|---|---|---|---|
| BMC Pregnancy and Childbirth | Laboratory detection protocols of VDR gene variants and their association with HDP. | Identified PCR-RFLP as the most frequently used protocol. Found an association between FokI variant and HDP in Asian populations. Highlights the importance of quality control in genotyping. | Objective and analytical |
Key Details & Data Points
- What: A systematic review of studies investigating the association between VDR gene variants and hypertensive disorders of pregnancy (HDP).
- Who: Researchers from Universiti Putra Malaysia and Ahmadu Bello University, among others.
- When: The systematic review included studies published until March 31, 2023, and was published on May 6, 2025.
- Where: The included studies were conducted in Asia (67%), Europe (22%), and Latin America (11%).
Key Statistics:
- Key statistic 1: 14% (HDP accounts for almost 14% of maternal mortality and morbidity globally)
- Key statistic 2: 67% (67% of studies used PCR-RFLP for VDR variant detection)
- Key statistic 3: 44% (44% of studies showed association of FokI variant reported in Asian populations)
Analysis & Context
The systematic review highlights the inconsistent association between VDR gene variants and HDP across different populations, potentially due to varying laboratory protocols and quality control measures. The review identifies PCR-RFLP as the most commonly used detection method, with associations found between the FokI variant and HDP, particularly in Asian populations. The findings emphasize the need for standardized, reliable detection methods and further research to explore population-specific biomarkers for personalized HDP management.
Conclusion
The systematic review concludes that there is an association between VDR gene variants and HDP. The review highlights the need for reliable detection protocols and stringent quality control measures to minimize discrepancies across populations. Integrating VDR variant screening into public health policies could potentially reduce the risks of HDP.
Disclaimer: This article was generated by an AI system that synthesizes information from multiple news sources. While efforts are made to ensure accuracy and objectivity, reporting nuances, potential biases, or errors from original sources may be reflected. The information presented here is for informational purposes and should be verified with primary sources, especially for critical decisions.
